Tesamorelin

Tesamorelin is a synthetic analog of human growth-hormone-releasing hormone (GHRH), supplied here as a 10 mg lyophilized (freeze-dried) research peptide for in-vitro and preclinical laboratory work only. Structurally it is a stabilized 44-residue peptide corresponding to the full-length GHRH(1-44) sequence, distinguished from native GHRH by an N-terminal trans-3-hexenoyl (unsaturated fatty-acid) modification. This acylation is the defining feature of the molecule in the research literature: it hinders recognition by dipeptidyl peptidase-IV (DPP-IV), the enzyme that rapidly clips the N-terminus of unmodified GHRH, and thereby extends the peptide's measurable half-life in experimental systems. Investigators frequently reference the compound by its development code TH9507.